April is Oral Cancer Awareness Month

This month marks 13th year for raising oral cancer awareness

The Oral Cancer Foundation (OCF) is encouraging the dental community to get involved in Oral Cancer Awareness Month this April 2012 by offering free oral cancer screenings to the public in an effort to raise awareness of this disease across the U.S.

Oral cancer screening for side of tongue

OCF is asking dental and medical professionals nationwide to act as the first line of defense against oral cancer through the process of early discovery, and to raise public awareness of this cause by opening their doors for at least a half-day, during the month of April, to screen members of their community.

Oral cancer is one of the few cancers that are on the rise in the U.S. When found early, oral cancers have an 80% or better survival rate. Unfortunately, most oral cancers are found in late stages, when the five-year survival rate plummets to about 30%. Late-stage diagnosis can be greatly reduced through increased public awareness of these facts, and OCF believes that a national program of opportunistic screenings is the best means of creating that awareness.

In April 2012, OCF will again join forces with both professional societies and private sector companies who are stakeholders in this disease. The ADA, the American Academy of Oral and Maxillofacial Surgery, the Academy of General Dentistry, and the American Academy of Oral Medicine form the core of the professional society sponsorship.

OCF has also aligned with Henry Schein, LED Dental, and Bristol-Myers Squibb, who are asking their customers to be active in this April's endeavor. In addition, the 21 treatment facilities with head and neck departments that participated in 2011's effort are expected to participate again in 2012.

With the help of these partners in 2011, OCF was able to create more than 2,000 screening sites/events, according to the foundation. These events, combined with seven major walk/run awareness events coordinated by OCF, resulted in more than 50,000 individual screenings for oral cancer during April alone.

Cancer-causing Agent Identified in Smokeless Tobacco

Oral carcinogen shown to induce cancer for snuff/chew users

April 2, 2012 -- A chemical present in smokeless tobacco products is a strong oral carcinogen, according to research being presented this week at the American Association for Cancer Research's annual meeting in Chicago.

Although smokeless tobacco products have long been linked with certain cancers, including those of the oral cavity and esophagus, this is the first study to identify a specific chemical present in smokeless tobacco products that induces oral cancer in animals, according to Silvia Balbo, PhD, research associate at the Masonic Cancer Center of the University of Minnesota.

"(S)-N'-nitrosonornicotine, or (S)-NNN, is the only chemical in smokeless tobacco known to cause oral cancer," Balbo said in a press release.

Balbo and colleagues administered (S)-NNN and (R)-NNN to four groups of 24 rats. The rats were given either (S)-NNN alone, (R)-NNN alone, a combination of both, or tap water. The total dose was approximately equivalent to the amount of (S)-NNN to which a smokeless tobacco user would be exposed from chronic use of these products.

All rats assigned to (S)-NNN alone or the combination of the two began losing weight after one year of exposure and died by 17 months. Rats assigned to (R)-NNN or tap water were terminated at 20 months.

All rats assigned to (S)-NNN had esophageal tumors and demonstrated 100% incidence of oral tumors, including tumors of the tongue, buccal mucosa, soft palate, and pharynx. In contrast, researchers found oral tumors in only five of 24 rats given (R)-NNN and esophageal tumors in only three of 24 rats assigned to (R)-NNN.

Twelve rats given the combination of (S)-NNN and (R)-NNN had 153 esophageal tumors and 96 oral tumors.

Since the U.S. Food and Drug Administration regulates tobacco products, Balbo hopes the results of this study will inform regulatory decisions. Moving forward, she and her colleagues hope to identify other chemicals that may be carcinogens in smokeless tobacco and to understand what level of these chemicals is present in smokeless tobacco products.